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INI CET 2021 May
Antibiotic which interferes with protein metabolism:
a - Gentamicin
b - Chloramphenicol
c - Erythromycin
d - Vancomycin
Antimicrobial drugs according to Mechanism of action:
1. Inhibit cell wall synthesis: Penicillins, Cephalosporins, Cycloserine, Vancomycin, Bacitracin.
2. Cause leakage from cell membranes: Polypeptides—
Polymyxins, Colistin, Bacitracin. Polyenes—Amphotericin B, Nystatin, Hamycin.
3. Inhibit protein synthesis: Tetracyclines, Chloramphenicol, Erythromycin, Clindamycin, Linezolid.
4. Cause misreading of m-RNA code and affect permeability: Aminoglycosides— Streptomycin, Gentamicin, etc.
5. Inhibit DNA gyrase: Fluoroquinolones—Ciprofloxacin and others.
6. Interfere with DNA function: Rifampin.
7. Interfere with DNA synthesis: Acyclovir, Zidovudine.
8. Interfere with intermediary metabolism: Sulfonamides, Sulfones, PAS, Trimethoprim, Pyrimethamine, Metronidazole.