OPTION 3

 

•            Cemento-ossifying fibroma (COF) is a distinct form of a benign fibro-osseous tumor, affecting predominantly the craniofacial region. Cemento-ossifying fibroma was initially classified by the World Health Organization (WHO) as a fibro-osseous neoplasm. However, they do not arise in the long bones, and occur mostly in the tooth-bearing areas of the jaws.

•            Their resemblance to ossifying fibroma and cemento-osseous dysplasias give evidence for an odontogenic origin. They are derived from the mesenchymal blast cells of the periodontal ligament, and have a potential to form fibrous tissue, cement and bone or a combination of such elements.

•                           It was reported by Eversole et al that these cementum-like structures are associated with membranous bone, and may not be related to cementogenesis. Cemento-ossifying fibroma has always been surrounded by controversy regarding the terminology and criteria of diagnosis.

 

Panoramic radiograph reveals a well-defined multilocular radiolucent lesion in the right mandibular body region extending up to the ramus, with expansion of cortical plate and scattered diffuse radiopacity inside the radiolucent lesion

 

 

Key concept:

 

According to the new WHO classification of 2005, the term “cemento-ossifying ossifying fibroma” has been reduced to “ossifying fibroma” (OF). Thus, OF and COFs are considered odontogenic in origin, mainly from the periodontal ligament.