OPTION 1

Type 2 diabetes is often associated with other medical disorders; when these coexist, they are termed ‘metabolic syndrome’, with a predisposition to insulin resistance being the primary defect. It is strongly associated with macrovascular disease (coronary, cerebral, peripheral) and an excess mortality.
Features of the insulin resistance (metabolic) syndrome:
☻Hyperinsulinaemia
☻Type 2 diabetes or impaired glucose tolerance (IGT)
☻Hypertension
☻Dyslipidaemia (↑LDL cholesterol, ↑triglycerides,↑HDL cholesterol)
☻Non-alcoholic fatty liver
☻Central (visceral) obesity
☻Increased fibrinogen, uric acid
☻(In women) Polycystic ovarian syndrome

Key Concept:
Metabolic syndrome (MetS) is the commonly observed clustering of obesity, hypertension, dyslipidemia, and insulin resistance